VZ 185 | Tocris Bioscience 6936 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VZ 185

catalog :

6936

quantity :

5 mg

price :

259 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6936 - VZ 185 C53H67FN8O8S CAS No. 2306193-61-1

product information

brand :

Tocris

master code :

6936

SKU :

6936/5

product name :

VZ 185

description :

Potent and selective BRD7/9 Degrader

target :

Active Degraders

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

995.23

url print :

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details of functionality :

Potent and selective VHL-based dual degrader of BRD7/9 (DC50 values are 4 and 34 nM for BRD7 and BRD9, respectively). Exhibits selectivity for BRD7/9 degradation over other bromodomain-containing proteins and other BAF/PBAF subunits. Displays cytotoxicity towards EOL-1 and A-204 cancer cell lines. Negative control cis VZ 185 (Cat. No. 6939) also available.

catalog number base :

6936

product keywords :

VZ185 potent selective VHL active degraders degrades PROTACs protac BRD7 BRD9 targeted protein degradation tpd Active Degraders Bromodomains 6936, target protein knockdown, PROTAC, SNIPER

extended description :

Potent and selective BRD7/9 Degrader

chemical name text :

(2S,4R)-N-(2-((5-(4-(2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

formula :

C 53 H 67 FN 8 O 8 S

formula text :

C53H67FN8O8S

cas num :

2306193-61-1

2020 USD :

249

2021 USD :

259 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage