673 A | Tocris Bioscience 6934/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

673 A

catalog :

6934/10

quantity :

10 mg (also 50 mg)

price :

208 USD

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

6934

SKU :

6934/10

product name :

673 A

Description :

ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)

target :

Aldehyde Dehydrogenase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

223.28

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

673 A is an aldehyde dehydrogenase (ALDH1A) inhibitor (IC50 values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). Exhibits 40-fold selectivity for ALD1A over ALDH2. Depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). Overcomes chemotherapy resistance in vivo .

extended description :

ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)

chemical name text :

4-(1,3-Dihydro-2H-isoindol-2-yl)benzaldehyde

formula :

C 15 H 13 NO

formula text :

C15H13NO

cas num :

109437-62-9

USD :

208 USD

product details :

ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)

storage :

Store at -20°C