chemical

AMZ 30

6923/10

10 mg (also 50 mg)

137 USD

6923

6923/10

AMZ 30

Potent, selective and irreversible protein phosphatase methylesterase-1 (PME-1) inhibitor

Hydrolase Inhibitors

10 mg (also 50 mg)

Small Molecules

98%

Store at -20°C

461.45

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AMZ 30 is a potent, selective and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 600 nM) with 100-fold selectivity for PME-1 over other serine hydrolases in human cell lysates. AMZ 30 inactivates PME-1 and reduces the demethylated form of serine/threonine protein phosphatase 2A (PP2A) in HEK 293T cells. AMZ 30 perturbs leucine carboxyl methyltransferase-1 (LCMT1)-PME-1 methylation equilibrium leading to shortening of mitotic spindles and mitotic arrest in HeLa cells. It also shows antiproliferative properties in an in vitro model of endometrial carcinoma.

AMZ30 potent selective irreversible covalent inhibitor inhibits serine hydrolases protein phosphatase methylesterase-1 PME-1 mitotic arrest Other Hydrolases Mitosis 6923,

Potent, selective and irreversible protein phosphatase methylesterase-1 (PME-1) inhibitor

(2E)-2-[(4-Fluorophenyl)sulfonyl]-3-[1-[(3-nitrophenyl)sulfonyl]-1H-pyrrol-2-yl]-2-propenenitrile

C19H12FN3O6S2

C19H12FN3O6S2

1313613-09-0

152

137 USD

Potent, selective and irreversible protein phosphatase methylesterase-1 (PME-1) inhibitor