chemical

dTAGV-1

6914

5 mg

409 USD

6914

6914/5

dTAGV-1

Potent and selective degrader of mutant FKBP12F36V fusion proteins

TAG Degradation Platforms

Small Molecules

5 mg

98%

1361.58

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Degrader targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a von Hippel-Lindau (VHL)-binding ligand. Induces potent and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo . Selectively degrades FKBP12F36V-EWS/FLI fusion proteins and inhibits cell proliferation in FKBP12F36V-EWS/FLI-expressing Ewing sarcoma cells. . Negative control dTAGV-1-NEG (Cat. No. 6915) also available. . FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in. Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R&D Systems . Email TPD@bio-techne.com to enquire. . Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.

6914

2451573-86-5 dTAGVHL1 degraders degrades targeted protein degradation FKBP12F36V fusion protein mutant PROTAC VHL von Hippel Lindau TPD TAG Degradation Platform 6914,

Potent and selective degrader of mutant FKBP12F36V fusion proteins

(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyph

C 68 H 90 N 6 O 14 S CF 3 CO 2 H

C68H90N6O14S CF3CO2H

409

409 USD

Store at -20°C