dTAGV-1 | Tocris Bioscience 6914/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

dTAGV-1

catalog :

6914/5

quantity :

5 mg

price :

514 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Nirala B, Patel T, Kurenbekova L, Shuck R, Dasgupta A, Rainusso N, et al. MYC regulates CSF1 expression via microRNA 17/20a to modulate tumor-associated macrophages in osteosarcoma. JCI Insight. 2023;8: pubmed publisher
Naqvi S, Kim S, Hoskens H, Matthews H, Spritz R, Klein O, et al. Precise modulation of transcription factor levels identifies features underlying dosage sensitivity. Nat Genet. 2023;55:841-851 pubmed publisher
Bondeson D, Mullin Bernstein Z, Oliver S, Skipper T, Atack T, Bick N, et al. Systematic profiling of conditional degron tag technologies for target validation studies. Nat Commun. 2022;13:5495 pubmed publisher
Antony C, George S, Blum J, Somers P, Thorsheim C, Wu Corts D, et al. Control of ribosomal RNA synthesis by hematopoietic transcription factors. Mol Cell. 2022;82:3826-3839.e9 pubmed publisher
Abuhashem A, Hadjantonakis A. Generation of knock-in degron tags for endogenous proteins in mice using the dTAG system. STAR Protoc. 2022;3:101660 pubmed publisher
Damhofer H, Radzisheuskaya A, Helin K. Generation of locus-specific degradable tag knock-ins in mouse and human cell lines. STAR Protoc. 2021;2:100575 pubmed publisher

image

image 1 :

Cat.No. 6914 - dTAGV-1 C68H90N6O14S CF3CO2H

product information

brand :

Tocris

MasterCode :

6914

SKU :

6914/5

product name :

dTAGV-1

target :

TAG Degradation Platforms

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

1361.58

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

dTAGV-1 is a degrader targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a von Hippel-Lindau (VHL)-binding ligand. Induces potent and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo . Selectively degrades FKBP12F36V-EWS/FLI fusion proteins and inhibits cell proliferation in FKBP12F36V-EWS/FLI-expressing Ewing sarcoma cells. . Hydrochloride salt (Cat.No. 7374) available; suitable for in vivo use. . Negative control dTAGV-1-NEG (Cat. No. 6915) also available. . FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in. Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R D Systems . Email TPD@bio-techne.com to enquire. . Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.

extended description :

Potent and selective degrader of mutant FKBP12F36V fusion proteins

chemical name text :

(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyph

formula :

C 68 H 90 N 6 O 14 S CF 3 CO 2 H

formula text :

C68H90N6O14S CF3CO2H

cas num :

2624313-15-9

USD :

514 USD

product details :

Potent and selective degrader of mutant FKBP12F36V fusion proteins

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage