chemical

dTAG-7

6912

5 mg

409 USD

6912

6912/5

dTAG-7

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

TAG Degradation Platforms

Small Molecules

5 mg

98%

1210.32

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

First generation Degrader for mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. Application of dTAG-7 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo . dTAG is generalizable to a range of fusion proteins; useful as an alternative to genetic methods for target validation. See also dTAG-13 . . FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in. Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R&D Systems . Email TPD@bio-techne.com to enquire. . Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.

6912

dTAG7 dFKBP7 degraders degrades degradation FKBP12F36V fusion protein mutant PROTACs proteolysis targeting chimera TAG Degradation Platform 6912,

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

(1R)-3-(3,4-Dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

C 63 H 79 N 5 O 19

C63H79N5O19

2064175-32-0

389

409 USD

Store at -20°C