dTAG-7 | Tocris Bioscience 6912/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

dTAG-7

catalog :

6912/5

quantity :

5 mg

price :

514 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Ma D, Yuan Q, Peng F, Paredes V, Zeng H, Osikpa E, et al. Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation. J Am Chem Soc. 2023;: pubmed publisher
Cugusi S, Mitter R, Kelly G, Walker J, Han Z, Pisano P, et al. Heat shock induces premature transcript termination and reconfigures the human transcriptome. Mol Cell. 2022;82:1573-1588.e10 pubmed publisher
Ilik I, Malszycki M, Lübke A, Schade C, Meierhofer D, Aktas T. SON and SRRM2 are essential for nuclear speckle formation. elife. 2020;9: pubmed publisher

image

image 1 :

Cat.No. 6912 - dTAG-7 C63H79N5O19 CAS No. 2064175-32-0

product information

brand :

Tocris

MasterCode :

6912

SKU :

6912/5

product name :

dTAG-7

target :

TAG Degradation Platforms

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

1210.32

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

dTAG-7 is a first generation Degrader for mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. Application of dTAG-7 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo . dTAG is generalizable to a range of fusion proteins; useful as an alternative to genetic methods for target validation. See also dTAG-13 . . FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in. Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R D Systems . Email TPD@bio-techne.com to enquire. . Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.

extended description :

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

chemical name text :

(1R)-3-(3,4-Dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

formula :

C 63 H 79 N 5 O 19

formula text :

C63H79N5O19

cas num :

2064175-32-0

USD :

514 USD

product details :

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage