DPTIP | Tocris Bioscience 6903 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DPTIP

catalog :

6903

quantity :

10 mg (also 50 mg)

price :

185 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6903

SKU :

6903/10

product name :

DPTIP

description :

Potent and selective N-SMase2 inhibitor; brain penetrant

target :

Hydrolase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

378.45

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase. Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and in vivo . Attenuates IL-1 -induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain. Metabolically stable and brain penetrant.

catalog number base :

6903

product keywords :

neutral sphingomyelinase 2 nSMase2 inhibition inhibitors inhibits Sphingomyelin phosphodiesterase SMase metabolically stable brain penetrant bbb Other Hydrolases 6903,

extended description :

Potent and selective N-SMase2 inhibitor; brain penetrant

chemical name text :

2,6-Dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol

formula :

C 21 H 18 N 2 O 3 S

formula text :

C21H18N2O3S

cas num :

351353-48-5

2020 USD :

185

2021 USD :

185 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage