Dapansutrile | Tocris Bioscience 6902/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Dapansutrile

catalog :

6902/10

quantity :

10 mg (also 50 mg)

price :

96 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Wu X, Manske M, Ruan G, Witter T, Nowakowski K, Abeykoon J, et al. Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19. iScience. 2023;26:106929 pubmed publisher

product information

brand :

Tocris

MasterCode :

6902

SKU :

6902/10

product name :

Dapansutrile

target :

Inflammasomes Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

133.17

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dapansutrile is a NLRP3 inflammasome inhibitor that disrupts inflammasome formation. Reduces LPS/ATP-induced IL-1 secretion in human and mouse macrophages in vitro , without affecting TNF levels. Reduces LPS-induced inflammation in vivo . Also reduces joint swelling and markers of inflammation in synovial fluid in a mouse model of acute arthritis. Displays cardioprotective effects in a mouse model of cardiac ischemic reperfusion injury. . OLT1177 is a registered trademark of Olatec Therapeutics LLC in the United States and other countries.

extended description :

NLRP3 inflammasome inhibitor; disrupts inflammasome formation

chemical name text :

3-(Methylsulfonyl)propanenitrile

formula :

C 4 H 7 NO 2 S

formula text :

C4H7NO2S

cas num :

54863-37-5

USD :

96 USD

product details :

NLRP3 inflammasome inhibitor; disrupts inflammasome formation

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage