VU 0424465 | Tocris Bioscience 6895 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 0424465

catalog :

6895

quantity :

10 mg (also 50 mg)

price :

185 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6895 - VU 0424465 C19H19FN2O2 CAS No. 1428630-85-6

product information

brand :

Tocris

master code :

6895

SKU :

6895/10

product name :

VU 0424465

description :

Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity

target :

Group I mGluR Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

326.37

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent mGlu5 positive allosteric modulator (EC50 = 1.5 nM) and agonist (EC50 = 171 nM; maximum effect is 65% that of glutamate). Binds allosteric site with high affinity (Ki = 11.8 nM). Increases maximum response to glutamate by 30%. Exhibits bias towards signaling via IP1 and ERK1/2 over iCa2+ in HEK293 and neuronal cells, and activates Gs in HEK 293 cells. Induces epileptiform activity in CA3 hippocampal neurons in vitro and convulsions in vivo .

catalog number base :

6895

product keywords :

VU0424465 metabotropic glutamate receptor subtype 5 mGlu5 mGluR agonist positive allosteric modulators modulates agonists agonism potent high affinity Glutamate (Metabotropic) Group I Receptors 6895,

extended description :

Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity

chemical name text :

5-[2-(2-(3-Fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-2-pyridinecarboxamide

formula :

C 19 H 19 FN 2 O 2

formula text :

C19H19FN2O2

cas num :

1428630-85-6

2020 USD :

185

2021 USD :

185 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage