VU 6005649 | Tocris Bioscience 6893 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 6005649

catalog :

6893

quantity :

10 mg (also 50 mg)

price :

155 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6893

SKU :

6893/10

product name :

VU 6005649

description :

Positive allosteric modulators of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant

target :

Group III mGluR Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

357.28

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Positive allosteric modulator of mGlu7 and mGlu8 receptors (EC50 = 0.65 M and 2.6 M for mGlu7 and mGlu8, respectively). Displays 3.8 fold selectivity for mGlu7 and mGlu8 over other mGlu receptors (EC50 10 M for mGlu1,2,3,4,5,6). Also NK1 receptor antagonist (Ki= 650 nM, IC50 = 3.4 M). Brain penetrant.

catalog number base :

6893

product keywords :

VU6005649 positive allosteric modulators modulates PAM metabotropic glutamate receptor 7 8 group III mGlu neurokinin receptor 1 antagonists antagonism tachykinin NK1 Glutamate (Metabotropic) Group III Receptors NK1 Receptor 6893,

extended description :

Positive allosteric modulators of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant

chemical name text :

3-(2,3-Difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

formula :

C 16 H 12 F 5 N 3 O

formula text :

C16H12F5N3O

cas num :

2137047-43-7

2020 USD :

155

2021 USD :

155 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage