ML 67-33 | Tocris Bioscience 6886/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 67-33

catalog :

6886/10

quantity :

10 mg (also 50 mg)

price :

192 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
xc1 valos Prado P, Landra Willm A, Verkest C, Ribera A, Chassot A, Baron A, et al. TREK channel activation suppresses migraine pain phenotype. iScience. 2021;24:102961 pubmed publisher

image

image 1 :

Cat.No. 6886 - ML 67-33 C18H17Cl2N5 CAS No. 1443290-89-8

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6886

SKU :

6886/10

product name :

ML 67-33

description :

K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator

target :

Two-P Potassium Channels Activators

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

374.27

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ML 67-33 is a K2P potassium channel activator (EC50 values are 21.8 - 29.4 M, 30.2 M and 27.3 M for K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) respectively, expressed in xenopus oocytes). Increases channel currents by activating core gating apparatus of channels. In a mouse migraine model, ML 67-33 improves pain symptoms via activation of TREK 1/2 currents in trigeminal ganglion sensory neurons.

product keywords :

ML67-33 K2P potassium channel K2P2.1 K2P10.1 K2P4.1 TREK1 TREK2 TRAAK activators activates Two-P Potassium Channels 6886,

extended description :

K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator

chemical name text :

2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine

formula :

C18H17Cl2N5

formula text :

C18H17Cl2N5

cas num :

1443290-89-8

USD :

186

USD 2025 :

192 USD

product details :

K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator

more info or order :

Tocris Bioscience product webpage