TRPC6-PAM-C20 | Tocris Bioscience 6875/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TRPC6-PAM-C20

catalog :

6875/10

quantity :

10 mg (also 50 mg)

price :

225 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Zernov N, Veselovsky A, Poroikov V, Melentieva D, Bolshakova A, Popugaeva E. New Positive TRPC6 Modulator Penetrates Blood-Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice. Int J Mol Sci. 2022;23: pubmed publisher

image

image 1 :

Cat.No. 6875 - TRPC6-PAM-C20 C22H21NO4 CAS No. 667427-75-0

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6875

SKU :

6875/10

product name :

TRPC6-PAM-C20

description :

Selective positive allosteric modulator (PAM) of TRPC6

target :

TRPC Channel Activators

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

363.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. Selectively activates TRPC6 over other TRP channels. Also activates TRPA1. Induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 (EC50 = 2.37 M). Potentiates OAG (1-oleoyl-1-acetyl- sn -glycerol)-induced Ca2+ influx in human platelets, and enhances OAG-induced platelet aggregation.

product keywords :

Transient receptor potential canonical TRPC6 positive allosteric modulators modulates PAM platelet aggregation TRPC 6875,

extended description :

Selective positive allosteric modulator (PAM) of TRPC6

chemical name text :

3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one

formula :

C22H21NO4

formula text :

C22H21NO4

cas num :

667427-75-0

USD :

222

USD 2025 :

225 USD

product details :

Selective positive allosteric modulator (PAM) of TRPC6

more info or order :

Tocris Bioscience product webpage