AMG 333 | Tocris Bioscience 6874 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AMG 333

catalog :

6874

quantity :

10 mg (also 50 mg)

price :

169 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6874

SKU :

6874/10

product name :

AMG 333

description :

Potent and selective TRPM8 antagonist; active in vivo

target :

TRPM Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

453.33

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective TRPM8 antagonist (IC50 values are 13 and 20 nM for hTRPM8 and rTRPM8, respectively). Displays high selectivity over other TRP channels (IC50 20 M, TRPV1/V3/V4/A1). Inhibits icilin-induced wet-dog shake in rats and suppresses cold-induced increases in blood pressure in the rat cold-pressor test.

catalog number base :

6874

product keywords :

AMG333 Potent selective TRPM8 antagonists antagonism transient-receptor-potential melastatin 8 cold-temperature thermosensor TRPM 6874,

extended description :

Potent and selective TRPM8 antagonist; active in vivo

chemical name text :

6-[[[(S)-(3-Fluoro-2-pyridinyl)[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]amino]carbonyl]-3-pyridinecarboxylic acid

formula :

C 20 H 12 F 5 N 3 O 4

formula text :

C20H12F5N3O4

cas num :

1416799-28-4

2020 USD :

169

2021 USD :

169 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage