AMG 333 | Tocris Bioscience 6874/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AMG 333

catalog :

6874/10

quantity :

10 mg (also 50 mg)

price :

213 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Baumlin N, Silswal N, Dennis J, Niloy A, Kim M, Salathe M. Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells. Int J Mol Sci. 2023;24: pubmed publisher

image

image 1 :

Cat.No. 6874 - AMG 333 C20H12F5N3O4 CAS No. 1416799-28-4

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6874

SKU :

6874/10

product name :

AMG 333

description :

Potent and selective TRPM8 antagonist; active in vivo

target :

TRPM Blockers

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

453.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AMG 333 is a potent and selective TRPM8 antagonist (IC50 values are 13 and 20 nM for hTRPM8 and rTRPM8, respectively). Displays high selectivity over other TRP channels (IC50 20 M, TRPV1/V3/V4/A1). Inhibits icilin -induced wet-dog shake in rats and suppresses cold-induced increases in blood pressure in the rat cold-pressor test.

product keywords :

AMG333 Potent selective TRPM8 antagonists antagonism transient-receptor-potential melastatin 8 cold-temperature thermosensor TRPM 6874,

extended description :

Potent and selective TRPM8 antagonist; active in vivo

chemical name text :

6-[[[(S)-(3-Fluoro-2-pyridinyl)[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]amino]carbonyl]-3-pyridinecarboxylic acid

formula :

C20H12F5N3O4

formula text :

C20H12F5N3O4

cas num :

1416799-28-4

USD :

210

USD 2025 :

213 USD

product details :

Potent and selective TRPM8 antagonist; active in vivo

more info or order :

Tocris Bioscience product webpage