AZ 12799734 | Tocris Bioscience 6870/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZ 12799734

catalog :

6870/10

quantity :

10 mg (also 50 mg)

price :

230 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6870 - AZ 12799734 C18H18N4O3S CAS No. 1117684-36-2

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6870

SKU :

6870/10

product name :

AZ 12799734

description :

Potent TGF- RI inhibitor

target :

TGF-beta Receptor Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

370.43

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZ 12799734 is a potent inhibitor of transforming growth factor- type I receptor (TGF- ALK5) (IC50 = 17 nM in cellular inhibition assay and 47 nM in TGF- -induced luciferase activity assay). Also inhibits ALK4, ALK6 and ALK7 at concentrations under 10 M. Inhibits BMP signaling, phosphorylation of SMAD1 and SMAD2, and TGF- -induced epithelial cell migration in vitro . Displays cardiotoxicity in vivo . Orally bioavailable.

product keywords :

AZ12799734 TGF-?RI TGF-? TGF-betaRI ALK5 transforming growth factor beta receptor type 1 cell migration TGF-beta Receptors 6870,

extended description :

Potent TGF- RI inhibitor

chemical name text :

4-[[4-[(2.6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]benzenesulfonamide

formula :

C18H18N4O3S

formula text :

C18H18N4O3S

cas num :

1117684-36-2

USD :

255

USD 2025 :

230 USD

product details :

Potent TGF- RI inhibitor

more info or order :

Tocris Bioscience product webpage