Rhein | Tocris Bioscience 6867 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Rhein

catalog :

6867

quantity :

10 mg (also 50 mg)

price :

128 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6867

SKU :

6867/10

product name :

Rhein

description :

FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3

target :

Other Oxidase/Oxygenase Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

284.22

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 Ki = 1.8 M). Competitively binds enzyme at active site preventing binding of N6-methyladenosine (m6A) substrate and resulting in accumulation of DNA damage in cells. Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 M, respectively). Sensitizes glioblastoma cells to alkylating agents. Active in vivo .

catalog number base :

6867

product keywords :

mRNA N6-methyladenine demethylase FTO ALKBH9 Fat mass and obesity-associated protein alpha-ketoglutarate-dependent dioxygenase inhibitors inhibits competitive anti-inflammatory anticancer chemosensitizers chemosensitizing ALKBH2 ALKBH3 DNA damage r Other Oxygenases/Oxidases 6867,

extended description :

FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3

chemical name text :

9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid

formula :

C 15 H 8 O 6

formula text :

C15H8O6

cas num :

478-43-3

2020 USD :

125

2021 USD :

128 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage