Rhein | Tocris Bioscience 6867/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Rhein

catalog :

6867/10

quantity :

10 mg (also 50 mg)

price :

160 USD

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

6867

SKU :

6867/10

product name :

Rhein

Description :

FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3

target :

Other Oxidase/Oxygenase Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

284.22

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Rhein is a FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 Ki = 1.8 M). Competitively binds enzyme at active site preventing binding of N6-methyladenosine (m6A) substrate and resulting in accumulation of DNA damage in cells. Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 M, respectively). Sensitizes glioblastoma cells to alkylating agents. Active in vivo .

extended description :

FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3

chemical name text :

9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid

formula :

C 15 H 8 O 6

formula text :

C15H8O6

cas num :

478-43-3

USD :

160 USD

product details :

FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3

storage :

Store at -20°C