chemical

uPSEM 792 hydrochloride

6865

25 mg

764 USD

6865

6865/25

uPSEM 792 hydrochloride

Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant

Pharmacologically Selective Effector Molecules/PSEM

Small Molecules

25 mg

98%

277.75

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Ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and 10 nM for PSAM4-5HT3). Exhibits 10,000-fold agonist selectivity for PSAM4-GlyR over 7-GlyR, 7-5HT3, and 5HT3-R, and 230-fold selectivity over 4 2 nAChR. Also weak partial agonist (~10 %) at 4 2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo . Brain-penetrant.

6865

uPSEM792 hydrochloride ultrapotent PSEM uPSEM agonists agonsim PSAM4-GlyR PSAM4-5HT3 selective brain penetrant chemogenetics PSEMs Nicotinic (a4b2) Receptors 6865, Chemogenetics, Pharmacologically Selective Effector Molecules, PSAM Agonist, Pharmacologically Selective Actuator Module Agonists, PSEM, PSEMs

Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant

1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride

C 14 H 15 N 3 O.HCl

C14H15N3O.HCl

2341841-08-3

727

764 USD

Store at -20°C