uPSEM 792 hydrochloride | Tocris Bioscience 6865/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

uPSEM 792 hydrochloride

catalog :

6865/5

quantity :

5 mg (also 25 mg)

price :

235 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Lee J, Kim W, Park E, Cho J. Neocortical synaptic engrams for remote contextual memories. Nat Neurosci. 2022;: pubmed publisher
Zutshi I, Valero M, Fernández Ruiz A, Buzsaki G. Extrinsic control and intrinsic computation in the hippocampal CA1 circuit. Neuron. 2021;: pubmed publisher

product information

brand :

Tocris

MasterCode :

6865

SKU :

6865/5

product name :

uPSEM 792 hydrochloride

target :

PSEMs

category :

Small Molecules

unit size :

5 mg (also 25 mg)

purity :

98%

observed molecular weight :

277.75

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

uPSEM 792 hydrochloride is a ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and 10 nM for PSAM4-5HT3). Exhibits 10,000-fold agonist selectivity for PSAM4-GlyR over 7-GlyR, 7-5HT3, and 5HT3-R, and 230-fold selectivity over 4 2 nAChR. Also weak partial agonist (~10 %) at 4 2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo . Brain-penetrant.

extended description :

Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant

chemical name text :

1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride

formula :

C 14 H 15 N 3 O.HCl

formula text :

C14H15N3O.HCl

cas num :

2341841-08-3

USD :

235 USD

product details :

Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage