ABT 737 | Tocris Bioscience 6835/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ABT 737

catalog :

6835/10

quantity :

10 mg (also 50 mg)

price :

210 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6835 - ABT 737 C42H45ClN6O5S2 CAS No. 852808-04-9

product information

brand :

Tocris

master code :

6835

SKU :

6835/10

rank :

0.06

product name :

ABT 737

description :

Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

target :

Bcl-2 Family Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ABT 737 is a high affinity Bcl-2 family inhibitor (Ki 1nM for Bcl-XL, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing bcl-2 (EC50 1 M) and multiple myeloma cells (IC50 = 5-15 M). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.

extended description :

Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

chemical name text :

4-[4-[(4 -Chloro[1,1 -biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide

formula :

C42 H 45 ClN 6 O 5 S 2

formula text :

C42H45ClN6O5S2

cas num :

852808-04-9

USD :

210 USD

product details :

Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage