(R)-Shikonin | Tocris Bioscience 6829 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(R)-Shikonin

catalog :

6829

quantity :

10 mg (also 50 mg)

price :

78 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6829

SKU :

6829/10

product name :

(R)-Shikonin

description :

PTEN inhibitor; induces necroptosis; anti-inflammatory

target :

Protein Tyrosine Phosphatase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

288.3

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PTEN and inflammasome inhibitor. Inhibits PTEN s phosphatase activity (IC50 = 2.7 M) and NLRP3 activation. Also blocks TNF- and NF- B signaling. Attenuates HIV-1 replication at nanomolar concentrations. Suppresses glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2 (PKM2) (IC50 = 0.3 M). Induces necroptosis in MCF-7 and HEK293 cancer cell lines. Displays anti-inflammatory activity in a mouse model of collagen-induced arthritis.

catalog number base :

6829

product keywords :

PTEN inhibitors inhibits inducers necroptosis anti-inflammatory NLRP3 TNF- NF- B necroptosis HIV-1 replication pyruvate kinase M2 PKM2 NF-kappaB TNF-alpha alfa Protein Tyrosine Phosphatases Inflammasomes NF-kB/IkB Cytokines Other Kinases Necroptosis HIV 6829,

extended description :

PTEN inhibitor; induces necroptosis; anti-inflammatory

chemical name text :

5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione

formula :

C 16 H 16 O 5

formula text :

C16H16O5

cas num :

517-89-5

2020 USD :

2021 USD :

78 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage