AZ 1729 | Tocris Bioscience 6826/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZ 1729

catalog :

6826/10

quantity :

10 mg

price :

287 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6826 - AZ 1729 C18H16FN5OS CAS No. 2016864-46-1

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6826

SKU :

6826/10

product name :

AZ 1729

description :

FFA2 allosteric agonist; displays bias for the Gi signaling pathway

target :

Free Fatty Acid Receptor Agonists

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

369.42

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZ 1729 is a FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTP S binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro .

product keywords :

AZ1729 free fatty acid receptor 2 biased allosteric agonists agonism functional PAM NAM modulators modulates FFA2 GPCR biased signaling Free Fatty Acid Receptors 6826,

extended description :

FFA2 allosteric agonist; displays bias for the Gi signaling pathway

chemical name text :

4-Fluoro-N-[3-[2-[(aminoiminomethyl)amino]-4-methyl-5-thiazolyl]phenyl]benzamide

formula :

C18H16FN5OS

formula text :

C18H16FN5OS

cas num :

2016864-46-1

USD :

284

USD 2025 :

287 USD

product details :

FFA2 allosteric agonist; displays bias for the Gi signaling pathway

more info or order :

Tocris Bioscience product webpage