Selumetinib | Tocris Bioscience 6815 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Selumetinib

catalog :

6815

quantity :

50 mg

price :

91 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Huynh H, Soo K, Chow P, Tran E. Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. Mol Cancer Ther. 2007;6:138-46 pubmed

product information

brand :

Tocris

master code :

6815

SKU :

6815/50

product name :

Selumetinib

description :

Potent and selective MEK inhibitor; orally bioavailable

target :

LRP2

category :

Small Molecules

unit size :

50 mg

main entrez gene id :

4036

purity :

98%

observed molecular weight :

457.68

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective MEK inhibitor (IC50 = 14 nM for MEK1, Kd = 530 nM for MEK2). Inhibits ERK1/2 phosphorylation (IC50 = 10 nM). Exhibits no activity at p38 , MKK6, EGFR, ErbB2 and ERK2. Suppresses several cell lines containing B-Raf and Ras mutations, but displays no effect on a normal fibroblast cell lines. Inhibits tumor growth in colorectal tumor xenograft model. Orally bioavailable.

catalog number base :

6815

product keywords :

Potent selective MEK inhibitors inhibits ERK1/2 orally bioavailable active in vivo MEK 6815, LRP-2, LRP 2, low density lipoprotein receptor-related protein 2, Calcium Sensor Protein

extended description :

Potent and selective MEK inhibitor; orally bioavailable

chemical name text :

5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

formula :

C 17 H 15 BrClFN 4 O 3

formula text :

C17H15BrClFN4O3

cas num :

606143-52-6

2020 USD :

2021 USD :

91 USD

alt names :

calcium sensor protein, DBS, DBSlow-density lipoprotein receptor-related protein 2, EC 1.1.2.3, EC 3.4.21.9, Glycoprotein 330, GP330, Heymann nephritis antigen homolog, low density lipoprotein receptor-related protein 2, LRP2, LRP-2, megalin

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage