chemical

Sorafenib

6814

10 mg (also 50 mg)

70 USD

6814

6814/10

Sorafenib

Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR- , Flt-3 and cKIT

Raf Kinase Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

464.82

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

Potent Raf inhibitor (IC50 values are 6, 22 and 38 nM for Raf-1, wild-type BRAF and V599E BRAF mutant, respectively). Also inhibits mVEGFR-2, mVEGFR-3, mPDGFR- , Flt-3, cKIT and VEGFR-2 (IC50 values are 15, 20, 57, 58, 68 and 90 nM, respectively). Inhibits MAPK pathway in colon, pancreatic and breast cancer cells expressing mutant KRAS and mutant or wt BRAF in vitro . Exhibits antitumor activity in colon, breast and non small-cell lung cancer xenograft models. Also induces ferroptosis in hepatocellular carcinoma cells in vitro .

6814

potent Raf inhibitors multikinase inhibits BRAF KRAS MAPK signaling pathway anticancer VEGFR PDGFR beta Flt-3 cKIT Raf Kinase VEGFR PDGFR FLT3 Ferroptosis 6814,

Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR- , Flt-3 and cKIT

4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide

C 21 H 16 ClF 3 N 4 O 3

C21H16ClF3N4O3

284461-73-0

67

70 USD

Store at -20°C