Sorafenib | Tocris Bioscience 6814/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Sorafenib

catalog :

6814/10

quantity :

10 mg (also 50 mg)

price :

88 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Elkhadragy L, Dasteh Goli K, Totura W, Carlino M, Regan M, Guzman G, et al. Effect of CRISPR Knockout of AXIN1 or ARID1A on Proliferation and Migration of Porcine Hepatocellular Carcinoma. Front Oncol. 2022;12:904031 pubmed publisher

product information

brand :

Tocris

MasterCode :

6814

SKU :

6814/10

product name :

Sorafenib

target :

Raf Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

464.82

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Sorafenib is a potent Raf inhibitor (IC50 values are 6, 22 and 38 nM for Raf-1, wild-type BRAF and V599E BRAF mutant, respectively). Also inhibits mVEGFR-2, mVEGFR-3, mPDGFR- , Flt-3, cKIT and VEGFR-2 (IC50 values are 15, 20, 57, 58, 68 and 90 nM, respectively). Inhibits MAPK pathway in colon, pancreatic and breast cancer cells expressing mutant KRAS and mutant or wt BRAF in vitro . Exhibits antitumor activity in colon, breast and non small-cell lung cancer xenograft models. Also induces ferroptosis in hepatocellular carcinoma cells in vitro .

extended description :

Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR- , Flt-3 and cKIT

chemical name text :

4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide

formula :

C 21 H 16 ClF 3 N 4 O 3

formula text :

C21H16ClF3N4O3

cas num :

284461-73-0

USD :

88 USD

product details :

Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR- , Flt-3 and cKIT

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage