chemical

Ibrutinib

6813

10 mg (also 50 mg)

150 USD

6813

6813/10

Ibrutinib

Potent and selective BTK inhibitor

BTK

Small Molecules

10 mg (also 50 mg)

695

98%

440.5

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

Potent and selective BTK inhibitor (IC50= 0.5 nM). Selective for BTK against a screening panel of kinase enzymes. Inhibits autophosphorylation of BTK, phosphorylation of PLC , and phosphorylation of ERK (IC50 of 11 nM, 29 nM and 13 nM, respectively). Induces cytotoxicity of chronic lymphocytic leukemia (CLL) cells. Reduces clinical arthritis scores in a mouse model.

6813

Potent and selective Bruton tyrosine kinase inhibitor Btk Brutons Tyrosine Kinase (BTK) 6813, AT, ATK, BPK

Potent and selective BTK inhibitor

1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one

C 25 H 24 N 6 O 2

C25H24N6O2

936563-96-1

144

150 USD

Agammaglobulinaemia tyrosine kinase, AGMX1, AGMX1MGC126262, AT, ATKIMD1, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase, EC 2.7.10, EC 2.7.10.2, IMD1, PSCTK1, tyrosine-protein kinase BTK, XLA, XLAMGC126261

Store at -20°C