chemical

Afatinib dimaleate

6812

10 mg (also 50 mg)

89 USD

6812

6812/10

Afatinib dimaleate

Potent dual specificity EGFR/HER2 inhibitor; active in vivo

EGF Receptor Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

718.08

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

Potent dual specificity EGFR/HER2 inhibitor (IC50 are 0.4, 0.5, 10, 14, 1 nM for EGFRL858R, EGFRwt, EGFR L858R/T790M, ErbB2 (HER2) and ErbB4 (HER4), respectively). 100-fold more active than Gefitinib in L858R-T790M EGFR double mutant cell line. Irreversibly binds EGFR and HER2. Suppresses the kinase activity of wild-type and activated EGFR and HER2 mutants, including erlotinib-resistant isoforms. Induces tumor regression in xenograft and transgenic lung cancer models.

6812

BIBW2992 dual specificity EGFR HER2 inhibitors inhibits potent BIBW2992 EGFR 6812,

Potent dual specificity EGFR/HER2 inhibitor; active in vivo

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide dimaleate

C 24 H 25 ClFN 5 O 3 .2C 4 H 4 O 4

C24H25ClFN5O3.2C4H4O4

850140-73-7

89

89 USD

BIBW2992

Store at -20°C