Afatinib dimaleate | Tocris Bioscience 6812/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Afatinib dimaleate

catalog :

6812/10

quantity :

10 mg (also 50 mg)

price :

100 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Linnerbauer M, L xf6 xdf lein L, Vandrey O, Tsaktanis T, Beer A, Naumann U, et al. Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation. JCI Insight. 2022;7: pubmed publisher

image

image 1 :

Cat.No. 6812 - Afatinib dimaleate C24H25ClFN5O3.2C4H4O4 CAS No. 850140-73-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6812

SKU :

6812/10

product name :

Afatinib dimaleate

description :

Potent dual specificity EGFR/HER2 inhibitor; active in vivo

target :

EGF Receptor Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

718.08

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Afatinib dimaleate is a potent dual specificity EGFR/HER2 inhibitor (IC50 are 0.4, 0.5, 10, 14, 1 nM for EGFRL858R, EGFRwt, EGFR L858R/T790M, ErbB2 (HER2) and ErbB4 (HER4), respectively). 100-fold more active than Gefitinib in L858R-T790M EGFR double mutant cell line. Irreversibly binds EGFR and HER2. Suppresses the kinase activity of wild-type and activated EGFR and HER2 mutants, including erlotinib-resistant isoforms. Induces tumor regression in xenograft and transgenic lung cancer models.

product keywords :

BIBW2992 dual specificity EGFR HER2 inhibitors inhibits potent BIBW2992 EGFR 6812,

extended description :

Potent dual specificity EGFR/HER2 inhibitor; active in vivo

chemical name text :

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide dimaleate

formula :

C24H25ClFN5O3.2C4H4O4

formula text :

C24H25ClFN5O3.2C4H4O4

cas num :

850140-73-7

USD :

111

USD 2025 :

100 USD

product details :

Potent dual specificity EGFR/HER2 inhibitor; active in vivo

alt names :

BIBW2992

more info or order :

Tocris Bioscience product webpage