chemical

Lapatinib

6811

10 mg (also 50 mg)

48 USD

6811

6811/10

Lapatinib

Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor

EGF Receptor Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

581.06

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Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor (IC50 values are 9.8 and 10.2 nM, respectively). Selective for EGFR and ErbB-2 versus other proliferative kinases. Inhibits proliferation in multiple cancer cell lines (average IC50 values <0.16 M). Exhibits 100-fold average selectivity for the tumor cells versus human foreskin fibroblasts. Inhibits EGFR/ErbB2 autophosphorylation and phosphorylation of the downstream modulator AKT.

6811

Potent selective dual ErbB2 (HER-2) and EGFR inhibitors inhibits EGFR 6811,

Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor

N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine

C 29 H 26 ClFN 4 O 4 S

C29H26ClFN4O4S

231277-92-2

46

48 USD

Store at -20°C