Lapatinib | Tocris Bioscience 6811/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Lapatinib

catalog :

6811/10

quantity :

10 mg (also 50 mg)

price :

60 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Wangzhou A, Paige C, Neerukonda S, Naik D, Kume M, David E, et al. A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets. Sci Signal. 2021;14: pubmed publisher

product information

brand :

Tocris

MasterCode :

6811

SKU :

6811/10

product name :

Lapatinib

target :

EGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

581.06

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Lapatinib is a potent and selective dual ErbB2 (HER-2) and EGFR inhibitor (IC50 values are 9.8 and 10.2 nM, respectively). Selective for EGFR and ErbB-2 versus other proliferative kinases. Inhibits proliferation in multiple cancer cell lines (average IC50 values <0.16 M). Exhibits 100-fold average selectivity for the tumor cells versus human foreskin fibroblasts. Inhibits EGFR/ErbB2 autophosphorylation and phosphorylation of the downstream modulator AKT.

extended description :

Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor

chemical name text :

N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine

formula :

C 29 H 26 ClFN 4 O 4 S

formula text :

C29H26ClFN4O4S

cas num :

231277-92-2

USD :

60 USD

product details :

Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage