Dasatinib | Tocris Bioscience 6793/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Dasatinib

catalog :

6793/100

quantity :

100 mg

price :

134 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Gabbireddy S, Vosatka K, Chung A, Logue J. Melanoma cells adopt features of both mesenchymal and amoeboid migration within confining channels. Sci Rep. 2021;11:17804 pubmed publisher
Watson A, Grant A, Parker S, Hill S, Whalen M, Chakrabarti J, et al. Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning. Cell Rep. 2021;35:109293 pubmed publisher
Dai H, Chen R, Gui C, Tao T, Ge Y, Zhao X, et al. Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA. Stem Cell Res Ther. 2020;11:199 pubmed publisher
Quirós M, Feier D, Birkl D, Agarwal R, Zhou D, Garcia A, et al. Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing. Proc Natl Acad Sci U S A. 2020;117:9477-9482 pubmed publisher

product information

brand :

Tocris

MasterCode :

6793

SKU :

6793/100

product name :

Dasatinib

target :

Src Family Kinase Inhibitors

category :

Small Molecules

unit size :

100 mg

purity :

98%

observed molecular weight :

488.01

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dasatinib is a highly potent pan-Src/Bcr-Abl inhibitor (Ki values are 16 and 30 pM, respectively. Inhibits Bcr-Abl, Src, Lck, Fyn, c-kit and Yes with IC50 values in the subnanomolar range. Inhibits proliferation of tumor cells in vitro and exhibits anticancer acivity in vivo in a mouse chronic myelogenous leukemia (CML) xenograft model. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 2.1and 5.5 M, respectively). Dasatinib also enhances CD3-targeted lentiviral vector-mediated gene transfer by 3 to 10-fold. Targets and eliminates senescent cells. Orally bioavailable.

extended description :

Highly potent pan-Src/Bcr-Abl inhibitor

chemical name text :

N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide

formula :

C 22 H 26 ClN 7 O 2 S

formula text :

C22H26ClN7O2S

cas num :

302962-49-8

USD :

134 USD

product details :

Highly potent pan-Src/Bcr-Abl inhibitor

alt names :

BMS-354825

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage