chemical

Omipalisib

6792/10

10 mg (also 50 mg)

122 USD

6792

6792/10

Omipalisib

Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK

PI 3-Kinase Inhibitors

10 mg (also 50 mg)

Small Molecules

98%

Store at -20°C

505.5

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Omipalisib is a highly potent PI 3-K inhibitor (IC50 = 0.04 nM). Also inhibits mTOR (Ki = 0.18 - 0.3 nM) and DNA-PK (IC50 = 0.28 nM). Induces G1 cell cycle arrest and inhibits proliferation of some breast cancer cells lines in vitro . Reduces pAKT-S473 levels in and inhibits growth of BT474 breast cancer xenografts in mice. Orally bioavailable.

PI 3-Kinase PI3K mTOR DNA-PK highly potent inhibitors inhibits orally bioavailable anticancer GSK2126458 PI 3-Kinase DNA-dependent Protein Kinase mTOR 6792,

Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK

2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide

C25H17F2N5O3S

C25H17F2N5O3S

1086062-66-9

135

122 USD

Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK

GSK2126458