GSK 126 | Tocris Bioscience 6790/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 126

catalog :

6790/5

quantity :

5 mg

price :

99 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

MasterCode :

6790

SKU :

6790/5

product name :

GSK 126

target :

EZH2 Inhibitor

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

526.67

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 126 is a very high affinity and selective EZH2 inhibitor (Ki = 0.5 - 3 nM). Exhibits 150-fold selectivity for EZH2 over EZH1 and 1000-fold selectivity over 20 other human methyltransferases. Inhibits proliferation of B-cell lymphoma cell lines in vitro . Also inhibits H3K27Me3 and tumor growth in mice bearing BCL xenografts. Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection. Promotes the transition of ESCs to feeder-free extended pluripotent stem (EPS) cells in combination with LCDM cocktail .

extended description :

Very high affinity and selective EZH2 inhibitor

chemical name text :

N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide

formula :

C 31 H 38 N 6 O 2

formula text :

C31H38N6O2

cas num :

1346574-57-9

USD :

99 USD

product details :

Very high affinity and selective EZH2 inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage