Indisulam | Tocris Bioscience 6782 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Indisulam

catalog :

6782

quantity :

25 mg

price :

397 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6782

SKU :

6782/25

product name :

Indisulam

description :

Molecular glue; pre-mRNA splicing modulator

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

385.84

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Acts as a molecular glue to induce proteosomal degradation of mRNA splicing factor RBM39 (also designated CAPER , HCC1, FSAP59, and RNPC2), via binding to DCAF15. Acts as a pre-mRNA splicing modulator (SPLAMs; splicing inhibitor sulfonamides), causes aberrant pre-mRNA splicing. Suppresses proliferation of cancer cell lines. Reduces viability of HCT-116 cells (IC50 = 0.56 M). Induces cell cycle arrest in the G1 phase in cancer cell lines. Also a high affinity carbonic anhydrase isozyme XII (hCA XII) inhibitor (Ki = 3.0-5.7 nM).

catalog number base :

6782

product keywords :

High affinity carbonic anhydrase isozyme XII (hCA XII) inhibitors inhibits SPLAMs splicing inhibitor sulfonamides RNAbinding protein 39 RBM39 antiglaucoma Pre-mRNA splicing modulator molecular glue Carbonic anhydrases DNA, RNA and Protein Synthesis Ubiquitin E3 Ligases Biochemicals and Molecular Biology Cell Cycle Inhibitors Molecular Glues 6782, E3 Ligase

extended description :

Molecular glue; pre-mRNA splicing modulator

chemical name text :

N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide

formula :

C 14 H 12 ClN 3 O 4 S 2

formula text :

C14H12ClN3O4S2

cas num :

165668-41-7

2020 USD :

385

2021 USD :

397 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage