chemical

S 38093

6778

25 mg

278 USD

6778

6778/25

S 38093

Selective H3 antagonist and inverse agonist; also 1 receptor antagonist; antinociceptive

Histamine H3 Receptor Antagonists

Small Molecules

25 mg

98%

288.39

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H3 antagonist and inverse agonist (Ki values are 8.8, 1.2 and 1.44 M, at rat, human and mouse, respectively). Exhibits no activity at other histaminergic receptors. Antagonizes agonist action at mouse H3 receptors (KB = 0.65 M). Displays inverse agonist action in cells expressing a high H3 receptor density, (EC50 values are 9 and 1.7 M, at human and rat H3 receptors, respectively). Exhibits antihyperalgesic effect in a mouse diabetic neuropathy model in vivo . Promotes hippocampal neurogenesis in a mouse Alzheimer s disease model. Antinociceptive and procognitive. Also 1 receptor antagonist. Exhibits 30-fold selecitivity for 1 over H3 and occupies 1 but not H3 receptors at procognitive does in mice.

6778

S38093 H3 agonists Receptors Histamine histaminergic selective H3 antagonists antagonism inverse agonists agonism antinociceptive 1 sigma1 procognitive Histamine H3 Receptors Sigma1 Receptors 6778,

Selective H3 antagonist and inverse agonist; also 1 receptor antagonist; antinociceptive

rel-4-[3-[(3aR,6aS)-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy]benzamide

C 17 H 24 N 2 O 2

C17H24N2O2

1403835-45-9

269

278 USD

Store at -20°C