TAK 375 | Tocris Bioscience 6777/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TAK 375

catalog :

6777/10

quantity :

10 mg (also 50 mg)

price :

115 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Leem J, Bai G, Kim J, Oh J. Melatonin protects mouse oocytes from DNA damage by enhancing nonhomologous end-joining repair. J Pineal Res. 2019;67:e12603 pubmed publisher

image

image 1 :

Cat.No. 6777 - TAK 375 C16H21NO2 CAS No. 196597-26-9

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6777

SKU :

6777/10

product name :

TAK 375

description :

Very high affinity and selective melatonin receptor agonist

target :

Melatonin (MT) Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

259.34

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TAK 375 is a very high affinity and selective melatonin agonist (Ki values are 14 and 112 pM for human MT1 and MT2, respectively). Selective for human MT1 and MT2 over hamster MT3 and a range of other targets including benzodiazepine, opiate and dopamine receptors, ion channels and transporters. Accelerates return to normal circadian rhythm in rats after phase shift, without affecting learning and memory. Also reduces infarct size in rat heart in vitro post ischemia-reperfusion.

product keywords :

TAK375 melatonin receptor agonists agonism selective very high affinity MT1 MT2 circadian rhythm Ramelteon Melatonin (MT) Receptors 6777,

extended description :

Very high affinity and selective melatonin receptor agonist

chemical name text :

N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide

formula :

C16H21NO2

formula text :

C16H21NO2

cas num :

196597-26-9

USD :

127

USD 2025 :

115 USD

product details :

Very high affinity and selective melatonin receptor agonist

alt names :

Ramelteon

more info or order :

Tocris Bioscience product webpage