chemical

JTP 103237

6765

10 mg (also 50 mg)

199 USD

6765

6765/10

JTP 103237

Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor

Other Transferase Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

474.52

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Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor (IC50 = 20 - 40 nM). Displays 7000-fold selectivity for human MOGAT2 over human DGAT2. Modulates intestinal lipid absorption in mice. Decreases triglyceride, diacylglycerol and fatty acid synthesis in mouse model of fatty liver. Chronic treatment decreases hepatic triglyceride content and body weight, and improves glucose tolerance in diet-induced obese mice.

6765

JTP103237 monoacyglycerol acyltransferase MGAT2 inhibitors inhibits potent selective antiobesity triglyceride synthesis DGAT2L MOGAT2 Other Transferases Other Lipid Metabolism 6765,

Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor

7-[4,6-Bis(1,1-dimethylethyl)-2-pyrimidinyl]-5,6,7,8-tetrahydro-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazolo[4,3-a]pyrazine

C 24 H 29 F 3 N 6 O

C24H29F3N6O

1883864-16-1

199

199 USD

Store at -20°C