chemical

Raphin 1

6760

10 mg (also 50 mg)

155 USD

6760

6760/10

Raphin 1

Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant

Protein Ser/Thr Phosphatase Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

231.08

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Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase (Kd = 33 nM). Displays 30-fold selectivity for PPP1R15B over PPP1R15A. Inhibits PPP1R15B-mediated dephosphorylation and protein synthesis in vitro . Induces transient reduction in protein synthesis in brains of wild type mice after single dose. Decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in a mouse model of Huntington s disease. Orally bioavailable and brain penetrant.

6760

Raphin1 protein phosphatase 1 regulatory subunit 15B inhibitors inhibits protein synthesis PPP1R15B huntingtin Protein Ser/Thr Phosphatases 6760,

Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant

(2E)-2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide

C 8 H 8 Cl 2 N 4

C8H8Cl2N4

2022961-17-5

150

155 USD

Store at -20°C