Raphin 1 | Tocris Bioscience 6760/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Raphin 1

catalog :

6760/10

quantity :

10 mg (also 50 mg)

price :

195 USD

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6760

SKU :

6760/10

product name :

Raphin 1

description :

Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant

target :

Protein Ser/Thr Phosphatase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

231.08

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Raphin 1 is an inhibitor of the regulatory subunit PPP1R15B of protein phosphatase (Kd = 33 nM). Displays 30-fold selectivity for PPP1R15B over PPP1R15A. Inhibits PPP1R15B-mediated dephosphorylation and protein synthesis in vitro . Induces transient reduction in protein synthesis in brains of wild type mice after single dose. Decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in a mouse model of Huntington s disease. Orally bioavailable and brain penetrant.

product keywords :

Raphin1 protein phosphatase 1 regulatory subunit 15B inhibitors inhibits protein synthesis PPP1R15B huntingtin Protein Ser/Thr Phosphatases 6760,

extended description :

Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant

chemical name text :

(2E)-2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide

formula :

C8H8Cl2N4

formula text :

C8H8Cl2N4

cas num :

2022961-17-5

USD :

193

USD 2025 :

195 USD

product details :

Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant