AA 147 | Tocris Bioscience 6759/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AA 147

catalog :

6759/5

quantity :

5 mg (also 25 mg)

price :

90 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Woodley K, Dillingh L, Giotopoulos G, Madrigal P, Rattigan K, Philippe C, et al. Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nat Commun. 2023;14:2132 pubmed publisher
Ikeda S, Kurihara T, Jiang X, Miwa Y, Lee D, Serizawa N, et al. Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes. Nat Commun. 2022;13:5859 pubmed publisher
Cheng N, Shi J, Jin Y, Shi Y, Liu X, Zhang H, et al. Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats. Front Surg. 2021;8:665260 pubmed publisher
Shen Y, Li R, Yu S, Zhao Q, Wang Z, Sheng H, et al. Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice. J Am Heart Assoc. 2021;10:e020216 pubmed publisher
Charbord J, Ren L, Sharma R, Johansson A, Agren R, Chu L, et al. In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR. Nat Metab. 2021;3:682-700 pubmed publisher

product information

brand :

Tocris

MasterCode :

6759

SKU :

6759/5

product name :

AA 147

target :

Other ER Stress/UPR Activators

category :

Small Molecules

unit size :

5 mg (also 25 mg)

purity :

98%

observed molecular weight :

255.31

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 M).

extended description :

ER proteostasis regulator

chemical name text :

N-(2-Hydroxy-5-methylphenyl)benzenepropanamide

formula :

C 16 H 17 NO 2

formula text :

C16H17NO2

cas num :

393121-74-9

USD :

90 USD

product details :

ER proteostasis regulator

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage