TH 5487 | Tocris Bioscience 6749 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TH 5487

catalog :

6749

quantity :

10 mg (also 50 mg)

price :

223 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6749

SKU :

6749/10

product name :

TH 5487

description :

Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

target :

Glycosylase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

541.18

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 342 nM). Selective for OGG1 over other base excision repair enzymes. Inhibits OGG1 binding to 8-oxoG in DNA and suppresses proinflammatory gene expression in TNF- stimulated lung epithelial cells in vitro . Also inhibits proinflamatory gene expression and neutrophil recruitment in TNF- -challenged mouse lungs in vivo .

catalog number base :

6749

product keywords :

TH5487 OGG1 inhibitors inhibits selective 8-oxoguanine DNA glycosylase 1 repair enzymes anti-inflammatory Glycosylases 6749,

extended description :

Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

chemical name text :

4-(4-Bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide

formula :

C 19 H 18 BrIN 4 O 2

formula text :

C19H18BrIN4O2

cas num :

2304947-71-3

2020 USD :

214

2021 USD :

223 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage