TH 5487 | Tocris Bioscience 6749/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TH 5487

catalog :

6749/10

quantity :

10 mg (also 50 mg)

price :

251 USD

citations: 2

Reference
Guo S, Fang J, Xu W, Ortega J, Liu C, Gu L, et al. Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSα facilitates processing of oxidative DNA damage in human cells. J Biol Chem. 2022;298:102102 pubmed publisher
Behrouzi A, Xia H, Thompson E, Kelley M, Fehrenbacher J. Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons. Int J Mol Sci. 2022;23: pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6749

SKU :

6749/10

product name :

TH 5487

description :

Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

target :

Glycosylase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

541.18

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 342 nM). Selective for OGG1 over other base excision repair enzymes. Inhibits OGG1 binding to 8-oxoG in DNA and suppresses proinflammatory gene expression in TNF- stimulated lung epithelial cells in vitro . Also inhibits proinflamatory gene expression and neutrophil recruitment in TNF- -challenged mouse lungs in vivo .

product keywords :

TH5487 OGG1 inhibitors inhibits selective 8-oxoguanine DNA glycosylase 1 repair enzymes anti-inflammatory Glycosylases 6749,

extended description :

Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

chemical name text :

4-(4-Bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide

formula :

C19H18BrIN4O2

formula text :

C19H18BrIN4O2

cas num :

2304947-71-3

USD :

278

USD 2025 :

251 USD

product details :

Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor