TL 13-112 | Tocris Bioscience 6745 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TL 13-112

catalog :

6745

quantity :

5 mg

price :

367 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6745

SKU :

6745/5

product name :

TL 13-112

description :

Selective ALK Degrader

target :

Active Degraders

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

1002.57

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective anaplastic lymphoma kinase (ALK) degrader (DC50 values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302) conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h. . Negative control TL 13-110 (Cat. No. 6746) also available.

catalog number base :

6745

product keywords :

TL13-112 protac protacs targeted protein degradation TPD active degraders degrades ALK Anaplastic Lymphoma Kinase degronimides Active Degraders ALK 6745, target protein knockdown, PROTAC, SNIPER

extended description :

Selective ALK Degrader

chemical name text :

N-[2-[2-[2-[4-[4-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetamide

formula :

C 49 H 60 ClN 9 O 10 S

formula text :

C49H60ClN9O10S

cas num :

2229037-19-6

2020 USD :

352

2021 USD :

367 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage