TL 13-112 | Tocris Bioscience 6745/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TL 13-112

catalog :

6745/5

quantity :

5 mg

price :

447 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Ma D, Yuan Q, Peng F, Paredes V, Zeng H, Osikpa E, et al. Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation. J Am Chem Soc. 2023;: pubmed publisher
Mura G, Karaca Atabay E, Menotti M, Martinengo C, Ambrogio C, Giacomello G, et al. Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma. Front Oncol. 2022;12:1085672 pubmed publisher
Karaca Atabay E, Mecca C, Wang Q, Ambrogio C, Mota I, Prokoph N, et al. Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma. Blood. 2022;139:717-731 pubmed publisher

image

image 1 :

Cat.No. 6745 - TL 13-112 C49H60ClN9O10S CAS No. 2229037-19-6

product information

brand :

Tocris

catalog number base :

6745

SKU :

6745/5

product name :

TL 13-112

units size :

5 mg

description :

Selective ALK Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1002.57

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TL 13-112 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC ) (DC50 values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302) conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h. . Negative control TL 13-110 (Cat. No. 6746), and ALK antibody validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF4210 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Selective ALK Degrader (PROTAC )

extended description :

Selective ALK Degrader (PROTAC )

chemical name text :

N-[2-[2-[2-[4-[4-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetamide

formula :

C49H60ClN9O10S

formula text :

C49H60ClN9O10S

cas num :

2229037-19-6

USD :

447 USD

product details :

Selective ALK Degrader (PROTAC )

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage