TL 13-12 | Tocris Bioscience 6744 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TL 13-12

catalog :

6744

quantity :

5 mg

price :

363 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6744

SKU :

6744/5

product name :

TL 13-12

description :

Selective ALK degrader

target :

Active Degraders

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

961.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective anaplastic lymphoma kinase (ALK) degrader (DC50 values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302), conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat.No. 6745). Maximum degradation is exhibited at 16 h. . Negative control TL 13-22 (Cat. No. 6747) also available.

catalog number base :

6744

product keywords :

TL13-12 protac protacs targeted protein degradation TPD active degraders degrades ALK Anaplastic Lymphoma Kinase Active Degraders ALK 6744, target protein knockdown, PROTAC, SNIPER

extended description :

Selective ALK degrader

chemical name text :

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

formula :

C 45 H 53 ClN 10 O 10 S

formula text :

C45H53ClN10O10S

cas num :

2229037-04-9

2020 USD :

352

2021 USD :

363 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage