TL 13-12 | Tocris Bioscience 6744/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TL 13-12

catalog :

6744/5

quantity :

5 mg

price :

442 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Ma D, Yuan Q, Peng F, Paredes V, Zeng H, Osikpa E, et al. Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation. J Am Chem Soc. 2023;: pubmed publisher

image

image 1 :

Cat.No. 6744 - TL 13-12 C45H53ClN10O10S CAS No. 2229037-04-9

product information

brand :

Tocris

catalog number base :

6744

SKU :

6744/5

product name :

TL 13-12

units size :

5 mg

description :

Selective ALK Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

961.48

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TL 13-12 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC ) (DC50 values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302), conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat. No. 6745). Maximum degradation is exhibited at 16 h. . Negative control TL 13-22 (Cat. No. 6747) and ALK antibody validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF4210 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Selective ALK Degrader (PROTAC )

extended description :

Selective ALK Degrader (PROTAC )

chemical name text :

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

formula :

C45H53ClN10O10S

formula text :

C45H53ClN10O10S

cas num :

2229037-04-9

USD :

442 USD

product details :

Selective ALK Degrader (PROTAC )

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage