TL 13-12 | Tocris Bioscience 6744/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TL 13-12

catalog :

6744/5

quantity :

5 mg

price :

442 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Ma D, Yuan Q, Peng F, Paredes V, Zeng H, Osikpa E, et al. Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation. J Am Chem Soc. 2023;: pubmed publisher

image

image 1 :

Cat.No. 6744 - TL 13-12 C45H53ClN10O10S CAS No. 2229037-04-9

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6744

SKU :

6744/5

product name :

TL 13-12

description :

Selective ALK Degrader (PROTAC )

target :

Active Degraders

unit size :

5 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

961.48

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TL 13-12 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC ) (DC50 values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302), conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat. No. 6745). Maximum degradation is exhibited at 16 h. . Negative control TL 13-22 (Cat. No. 6747) and ALK antibody validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF4210 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

product keywords :

TL13-12 protac protacs targeted protein degradation TPD active degraders degrades ALK Anaplastic Lymphoma Kinase ALK Kinase Degraders 6744, target protein knockdown, PROTAC, SNIPER

extended description :

Selective ALK Degrader (PROTAC )

chemical name text :

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

formula :

C45H53ClN10O10S

formula text :

C45H53ClN10O10S

cas num :

2229037-04-9

USD :

428

USD 2025 :

442 USD

product details :

Selective ALK Degrader (PROTAC )

more info or order :

Tocris Bioscience product webpage