A 77-01 | Tocris Bioscience 6712/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 77-01

catalog :

6712/5

quantity :

5 mg (also 25 mg)

price :

167 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Orzechowska E, Katano T, Bialkowska A, Yang V. Interplay among p21Waf1/Cip1, MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-CreER reserve intestinal stem cells after gamma radiation-induced injury. Sci Rep. 2020;10:18300 pubmed publisher

image

image 1 :

Cat.No. 6712 - A 77-01 C18H14N4 CAS No. 607737-87-1

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6712

SKU :

6712/5

product name :

A 77-01

description :

Potent inhibitor of TGF- RI

target :

TGF-beta Receptor Inhibitors

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

286.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A 77-01 is a potent TGF- RI (ALK-5) inhibitor (IC50 = 34 nM). Inhibits TGF- transcriptional activation. Inhibits TGF- -induced proliferation of lung epithelial cells and SMAD phosphorylation. Inhibits TGF- -induced epithelial-to-mesenchymal transition (EMT). Also inhibitor of p38 MAPK. Likely active metabolite of A 83-01 (Cat. No. 2939).

product keywords :

A77-01 A7701 transforming growth factor receptor TGF B beta type I receptor kinase inhibitors inhibits potent p38 MAPK A 83-01 A83-01 TGF-beta Receptors p38 BMP and Other Activin Receptors 6712,

extended description :

Potent inhibitor of TGF- RI

chemical name text :

4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline

formula :

C18H14N4

formula text :

C18H14N4

cas num :

607737-87-1

USD :

185

USD 2025 :

167 USD

product details :

Potent inhibitor of TGF- RI

more info or order :

Tocris Bioscience product webpage