PA 8 | Tocris Bioscience 6657/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PA 8

catalog :

6657/10

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Varodayan F, Minnig M, Steinman M, Oleata C, Riley M, Sabino V, et al. PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology. 2020;168:107752 pubmed publisher

product information

brand :

Tocris

master code :

6657

SKU :

6657/10

rank :

0.06

product name :

PA 8

description :

PAC1 receptor antagonist

target :

PACAP Receptor Antagonists

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PA 8 is a PAC1 receptor antagonist. Inhibits PACAP-induced CREB phosphorylation in PAC1, but not VPAC1 or VPAC2, expressing cells. Also inhibits PACAP-induced increases in cAMP levels in vitro (IC50 = 2 nM) and PACAP-induced aversive responses and mechanical allodynia following intrathecal injection in vivo .

extended description :

PAC1 receptor antagonist

chemical name text :

2-Amino-5,8-dihydro-5-[3-methoxy-4-(2-propen-1-yloxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione

formula :

C 17 H 18 N 4 O 4

formula text :

C17H18N4O4

cas num :

878437-15-1

USD :

195 USD

product details :

PAC1 receptor antagonist

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage