VAS 2870 | Tocris Bioscience 6654/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VAS 2870

catalog :

6654/5

quantity :

5 mg (also 25 mg)

price :

85 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Liu D, Li Q, Ding H, Zhao G, Wang Z, Cao C, et al. Placenta-derived IL-32β activates neutrophils to promote preeclampsia development. Cell Mol Immunol. 2021;18:979-991 pubmed publisher

image

image 1 :

Cat.No. 6654 - VAS 2870 C18H12N6OS CAS No. 722456-31-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6654

SKU :

6654/5

product name :

VAS 2870

description :

NADPH oxidase (Nox) inhibitor

target :

NADPH Oxidase Inhibitors

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

360.39

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

VAS 2870 is a NADPH oxidase (Nox) inhibitor. Inhibits PMA-stimulated oxidative burst in HL-60 cells (IC50 = 2 M). Inhibits oxidized-LDL-mediated, but not basal, ROS production in HUVECs in vitro . Also inhibits PDGF-mediated Nox activation and ROS formation in vascular smooth muscle cells (VSMCs) and abolishes PDGF-dependent migration of VSMCs, while having no effect on proliferation. Enhances TGF- -induced apoptosis of liver tumor cells. Also inhibits platelet aggregation through a NOX-independent mechanism.

product keywords :

VAS2870 NADPH oxidase inhibitors inhibits nicotinamide adenine dinucleotide phosphate NOX reactive oxygen species ROS NADPH Oxidase 6654,

extended description :

NADPH oxidase (Nox) inhibitor

chemical name text :

7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine

formula :

C18H12N6OS

formula text :

C18H12N6OS

cas num :

722456-31-7

USD :

USD 2025 :

85 USD

product details :

NADPH oxidase (Nox) inhibitor

more info or order :

Tocris Bioscience product webpage